The first flight will leave Manchester Airport on December 11, initially transiting via Brussels.
The service will operate on Tuesday, Wednesday, Friday and Sunday, departing Terminal 2 at 18:05, arriving at Addis Ababa Bole International Airport at 06:45 and providing onward connectivity to the African continent.
Return flights depart Addis Ababa at 00:45, arriving in Manchester at 07:20 and have been scheduled to provide convenient connectivity.
“We are excited to commence our new service from Manchester on December 11”, says Michael Yohannes, Ethiopian Airlines' UK Country Manager.
“Along with the ten existing flights from Heathrow, inauguration of a four-weekly Manchester service makes Africa even more accessible along with some excellent connectivity to and from UK regional airports in conjunction with FlyBe, particularly Glasgow and Edinburgh.
“Passengers can look forward to convenient onward connections from Addis Ababa and unparalleled comfort on-board our Boeing 787 Dreamliner.”
To celebrate the launch the carrier is offering competitive fares across its network, including Addis Ababa from £5420, Johannesburg from £435, Nairobi from £445 and Cape Town from £452.
Fares are valid on bookings made before December 15, with travel dates between December 28 and June 30.